The invention discloses a needle shedding prevention device of an infusion apparatus. The device comprises an infusion apparatus needle and a shedding-prevention elastic cover, the upper end of the infusion apparatus needle is provided with a fixing block, the shedding-prevention elastic cover sleeves the infusion apparatus needle, and the upper end of the shedding-prevention elastic cover is fixed to the fixing block. When the needle shedding prevention device is spread by the shedding-prevention elastic cover, the infusion apparatus needle cannot shed, and when the shedding-prevention elastic cover is closed, medical staff can pull out the needle. The needle shedding prevention device can effectively prevent the infusion apparatus needle from accidentally shedding, and the infusion apparatus needle is prevented from being pulled out by a child or a coma and dysphoria patient; the waste of drugs or blood is avoided; the environment is prevented from being polluted; the situation is avoided that due to shedding of the needle, the workload of the medical staff is increased, and the patient or family members are frightened and worried; the waste of health resources is reduced; the occurrence of medical care accidents and the infusion cost are reduced.