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发明公开
CN109942661A 甘薯谷甾醇糖苷不饱和脂肪酸、提取物及其制备方法和应用 有权 转让

甘薯谷甾醇糖苷不饱和脂肪酸、提取物及其制备方法和应用
摘要：
本发明属于医药化学领域，具体涉及甘薯谷甾醇糖苷不饱和脂肪酸、提取物及其制备方法和应用,其中，甘薯谷甾醇糖苷亚麻酸酯对肿瘤细胞的生长抑制作用显著，在10mg/L给药浓度下，本发明的甘薯谷甾醇糖苷亚麻酸酯单体对MCF-7细胞的抑制率为92%，甘薯谷甾醇糖苷亚油酸酯单体对MCF-7细胞的抑制率为65%，甘薯谷甾醇糖苷单体对MCF-7细胞的抑制率为55%；1mg/L给药浓度下，对照甘薯谷甾醇糖苷亚麻酸酯单体对MCF-7细胞的抑制率为45%，甘薯谷甾醇糖苷亚油酸酯单体对MCF-7细胞的抑制率为15%，对照药物甘薯谷甾醇糖苷单体对MCF-7细胞的抑制率为10%。
摘要（英）：

The invention belongs to the field of medicinal chemistry, and particularly relates to sweet potato sitosterol glucoside unsaturated fatty acid and extract, as well as a preparation method and application thereof. Sweet potato sitosterol glucoside linolenate has a remarkable effect of inhibiting growth of tumor cells, wherein under 10mg/L drug concentration, a sweet potato sitosterol glucoside linolenate monomer has the inhibition ratio on a MCF-7 cell being 92 percent, a sweet potato sitosterol glucoside monolinoleate monomer has the inhibition ratio on the MCF-7 cell being 65 percent, and asweet potato sitosterol glucoside monomer has the inhibition ratio on the MCF-7 cell being 55 percent; and under 1mg/L drug concentration, a controlled sweet potato sitosterol glucoside linolenate monomer has the inhibition ratio on the MCF-7 cell being 45 percent, a controlled sweet potato sitosterol glucoside monolinoleate monomer has the inhibition ratio on the MCF-7 cell being 15 percent, anda controlled sweet potato sitosterol glucoside monomer has the inhibition ratio on the MCF-7 cell being 10 percent.

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