The invention relates to the field of fuel cladding tubes with relatively high neutron irradiation resistance, corrosion resistance and high temperature resistance in a nuclear reactor, in particularto a FeCrAl alloy and T91 ferrite/martensite heat-resistant steel composite tube for nuclear reactor nuclear fuel cladding and a manufacturing method for the FeCrAl alloy and T91 ferrite/martensite heat-resistant steel composite tube. The inner layer is a ferrite/martensite heat-resistant steel material, the outer layer is a FeCrAl alloy material, and an iron-based material auxiliary layer is arranged between the inner layer and the outer layer. The manufacturing method for the FeCrAl alloy and T91 ferrite/martensite heat-resistant steel composite tube comprises the following steps: surface polishing of seamless composite tube blank, degassing, assembling and packaging of seamless composite tube blank, thermal deformation processing metallurgical compounding, annealing thermal treatment, cold-rolled cold-drawing and intermediate annealing, final thermal treatment, straightening, cleaning and finished product inspecting. The method is characterized in that the outer layer, an intermediate transition layer and an inner-layer tube are assembled, are assembled and packaged into seamless composite tube blank after gas exhaustion, and are sealed by a welding end head; after being heated,the metallurgical compounded seamless composite tube blank formed by thermal deformation processing is finally subjected to cold-deformation processing to form a finished product of a needed specification.