The invention provides a technology for segmentation construction of a guiding pipe frame. The guiding pipe frame is divided into a plurality of segments and constructed on a sliding channel, and themultiple segmented guiding pipe frame bodies are transported to a final assembly site to be folded. The technology comprises the following steps that 1, the guiding pipe frame is divided into the multiple segments to be constructed separately; 2, a self-propelled modular transport vehicle travels to the position below the segmented guiding pipe frame bodies and jack the segmented guiding pipe frame bodies; 3, the self-propelled modular transport vehicle travels to a barge; 4, the self-propelled modular transport vehicle is fixed to the barge; 5, the barge travels off a wharf, and thus the self-propelled modular transport vehicle and the segmented guiding pipe frame bodies are transported to a wharf of the final assembly site; 6, after mooring of the barge is completed, the self-propelled modular transport vehicle travels to the final assembly site through a trestle; 7, on the final assembly site, the self-propelled modular transport vehicle is utilized to conduct final assembling and in-place of all the segments, and then the self-propelled modular transport vehicle is withdrawn; and 8, all the segments are folded step by step, and the overall guiding pipe frame is constructed. According to the technology, the construction efficiency of the guiding pipe frame is improved, the construction period of the guiding pipe frame is further shortened significantly, and the demands of the construction of the guiding pipe frame on the field are reduced.