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发明公开
CN109988179A 含吡唑结构N-苯基取代马来酰亚胺α-松油烯环加成衍生物及其制备方法和应用 有权 转让

含吡唑结构N-苯基取代马来酰亚胺α-松油烯环加成衍生物及其制备方法和应用
摘要：
本发明公开了一种含吡唑结构N‑苯基取代马来酰亚胺α‑松油烯环加成衍生物及其制备方法和应用，将1‑异丙基‑4‑甲基‑双环[2,2,2]‑5‑辛烯‑2,3‑二酸酐和苯胺分别溶解于丙酮溶剂中，在搅拌下将苯胺溶液滴加至含有1‑异丙基‑4‑甲基‑双环[2,2,2]‑5‑辛烯‑2,3‑二酸酐溶液的反应瓶，制备得到N‑苯基取代的马来酰亚胺α‑松油烯环加成产物，然后将N‑苯基取代的马来酰亚胺α‑松油烯环加成产物与6‑氟代色酮苯腙混合于无水乙醇中，加入氯胺T，制备得到的含吡唑结构N‑苯基取代马来酰亚胺α‑松油烯环加成衍生物对于癌细胞具有较强的抑制活性，为其用于潜在药物的开发研究提供了基础。
摘要（英）：

The invention discloses a pyrazole-containing structural N-phenyl substituted maleimide alpha-terpinene cycloaddition derivative as well as a preparation method and application thereof. The method comprises the following steps: dissolving 1-isopropyl-4-methyl-bicyclo[2,2,2]-5-octen-2,3-dianhydride into an acetone solvent, dissolving aniline into an acetone solvent, adding the aniline solution dropwise into a reaction bottle containing the 1-isopropyl-4-methyl-bicyclo[2,2,2]-5-octen-2,3-dianhydride solution under stirring to prepare a N-phenyl substituted maleimide alpha-terpinene cycloadditionproduct, mixing the N-phenyl substituted maleimide alpha-terpinene cycloaddition product and 6-fluorochromone phenylhydrazone in absolute ethanol, and adding chloramine-T to prepare the pyrazole-containing structural N-phenyl substituted maleimide alpha-terpinene cycloaddition derivative. The derivative provided by the invention has stronger inhibitory activity on cancer cells, and provides a basis for development and research of potential drugs.

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