The invention relates to a preparation method of a plant extract and application of the plant extract in preparation of medicaments/health-care products for treating/preventing hyperuricemia-related diseases, in particular to a preparation method of a five-fingered peach extract and application of the five-fingered peach extract in preparation of medicaments/health-care products for treating/preventing hyperuricemia-related diseases. The invention has the beneficial effects that: 1, The preparation process of the five-finger peach extract is simple, and the cost is low; 2, According to the method, ethanol, water or a mixed solvent of ethanol and water is used as a solvent to extract the five-finger peach, so that the problem of organic solvent pollution or residue does not exist, and the method is safe and environment-friendly; 3, The five-fingered peach extract disclosed by the invention has an obvious uric acid reducing effect and small side effect, can be used for preparing a medicament for relieving gout, and provides a new direction for improving the phenomenon that the side effect of the current gout medicament is large.