The invention discloses a manufacturing method of a personalized 3D printing insole. The manufacturing method comprises the following steps that (1) a whole foot is scanned through three-dimensional scanning equipment to obtain an stl model of the foot, and a plurality of curves are drawn on the sole and the side surface of the foot to describe a general outline of the sole of the foot; (2) a solefitting entity can be obtained by using modeling software with sole fitting curves; (3) stress analysis is carried out on the insole entity by using finite element software to analyze the stress magnitude on each part of the insole; (4) after the stress of each part of the insole is obtained through finite element software analysis, complex unit body arrays are realized through software, and stress distribution is obtained by increasing or decreasing the arrays or adjusting the density degree of the arrays; and (5) the insole in the step (4) is finally printed by a 3D printer to obtain the personalized 3D printed insole.