The invention discloses a one-time multilayer gravel filling tool for a large-span perforation section. The one-time multilayer gravel filling tool for the large-span perforation section comprises anouter-layer pipe column longitudinally penetrating through the whole perforation section, and a service pipe column arranged in the outer-layer pipe column. The outer-layer pipe column comprises, sequentially from bottom to top, a sand setting packer, an outer-layer pipe column main body part inserted into the upper part of the sand setting packer and a top packer assembly connected with the outer-layer pipe column main body part. the main body part of the outer-layer pipe column comprises a bottom operation pipe section, a middle operation pipe section and a sand prevention section; the sandprevention section, the middle operation pipe section and the bottom operation pipe section are all provided with sand prevention screen pipes corresponding to corresponding perforation layers and inner layer lining pipes of the sand prevention screen pipes, an annular space is formed between the inner layer lining pipes and the sand prevention screen pipes, and the inner layer lining pipes are connected with production circulation sliding sleeves; and the service pipe column mainly adopts a single-layer structure. The tool can be used for one-time multilayer gravel filling fracturing sand control operation of a large-span perforation section, and can realize layered mining without putting into a lower well completion production pipe column.