The invention discloses a boiler running control method for reducing water-cooled wall high-temperature corrosion influences. The running control method comprises the steps that the outlet oxygen volume of an economizer and the running manner of coal mills are adjusted, the average value of the outlet oxygen volume of the economizer is adjusted to be 3.0%-4.6%, and the rotation speed of a dynamicseparator of each coal mill is adjusted to be 60 rpm-75 rpm; and the output of the coal mills is controlled, the A mill output is 40 t/h-45 t/h, the B mill output is 42 t/h-49 t/h, the C mill output is 32 t/h-38 t/h, the D mill output is 33 t/h-40 t/h, the E mill output is 37 t/h-44 t/h, and the F mill output is 34 t/h-41 t/h. By adoption of the control method, front-back opposed combustion mannerboiler hearth combustion can be effectively improved, water-cooled wall face atmosphere parameters are improved, the boiler efficiency is improved, and the boiler water-cooled wall high-temperature corrosion influences are reduced.