The invention provides a control method for first criticality of a pressurized water reactor of a million-kilowatt-class nuclear power station, which comprises the following steps of: after the refueling treatment of the reactor, carrying out rod lifting treatment to ensure that the final rod position of an R rod is 170 steps and the final rod positions of other rods are 225 steps; after the rod lifting treatment, conducting diluting on a reactor core, and when any one of the conditions that the neutron countdown rate is equal to 0.1 and CB (mes) in a loop is equal to the sum of CB and 10 ppm is met, stopping the dilution treatment; and adjusting the rod position of the R rod to be greater than or equal to 150 steps until the first criticality is reached. According to the control method for the first criticality of the pressurized water reactor of the million-kilowatt-class nuclear power station, the problem that after refueling, the reactor R rod cannot successfullyreach the criticality at a time from 170 steps to the top (referred to as 'one-time R rod lifting' for short) is effectively and thoroughly solved.