The invention provides novel aromatic polyketone compounds as well as a preparation method and an application thereof. The compounds are prepared from streptomyces sp. N12W1565 through fermentation, and the streptomyces sp. N12W1565 is collected in CGMCC (China General Microbiological Culture Collection Center) with the collection number of CGMCC No.15050. The prepared aromatic polyketone compounds can be used for preparing a drug for preventing or treating PTP (protein-tyrosine phosphatase) mediated diseases.