The invention discloses an all-in-one machine mainboard based on a Shenwei processor and a domestic all-in-one machine. The all-in-one machine mainboard belongs to the technical field of computer application and comprises a central processing unit, a storage unit, a control unit and an expansion slot, wherein the central processing unit adopts the Shenwei processor, the Shenwei processor is connected with a south bridge chip and leads out a USB (universal serial bus) interface, a gigabit network interface, an audio interface, an extended m-PCIE (peripheral component interface express) interface, an MXM display card interface and a TCM trusted cryptography module slot, and at least two USB interfaces are respectively a rear interface and a side interface; the gigabit network is an adaptivenetwork, the m-PCIE interface is an mSATA compatible slot, and the mainboard is connected to a display screen and outputs LVDS signals. The domestic all-in-one machine comprises a machine shell, a support, the display screen and a mainboard installed in the machine shell, and the mainboard is the all-in-one machine mainboard. The all-in-one machine mainboard based on the Shenwei processor and thedomestic all-in-one machine can realize the same functions of the desktop computer, and are simple in structure, are safe and reliable and are suitable for various office environments.