The invention discloses a big power grid intelligent regulation and control system and method based on big data and artificial intelligence. According to the system and the method, artificial intelligence and a big data technology are utilized; through a distributed computing engine, based on wide-area actual measurement information, data analysis and mining are performed on an established power grid virtual equivalent model, unified quantitative evaluation and intelligent optimization decision control are performed on the online stability situation of a power grid, and meanwhile, the system and the method can also display collected data and analysis results in real time and perform man-machine interaction. Compared with the prior art, the intelligent mining depth of electric power data iseffectively improved, and the timeliness of power grid analysis decision making, the intelligent scheduling and control capacity of a large power grid and the online monitoring capacity and level ofthe large power grid are improved by utilizing the breadth and the management utilization and analysis capacity of the power grid on measurement data.