The invention discloses an anti-falling infusion device puncture device. The anti-falling infusion device puncture device comprises a puncture device main body and an anti-falling elastic cover, wherein the anti-falling elastic cover sleeves the puncture device main body, the upper end of the anti-falling elastic cover is fixedly arranged at the lower end of a needle tip of the puncture device main body, the lower end of the anti-falling elastic cover is connected with a second push piece through a cylinder and wraps the puncture device main body, and the lower end of the anti-falling elasticcover can slide at the lower end of the puncture device main body. The anti-falling infusion device puncture device can effectively prevent the infusion device puncture device from falling off accidentally, thereby avoiding adverse consequences, reducing the occurrence of medical accidents, preventing leakage containment, and protecting the safety of a patient and a medical worker; the change of an infusion hole avoid the situation that the treatment time of the patient is increased due to insufficient drug input of the patient caused by excessive liquid remaining in an infusion device, thereby avoiding waste, saving the resources and reducing the financial burden of the patient seeking medical care.