The invention relates to a multi-fluid re-boiler with kettle chambers connected in series. The multi-fluid re-boiler comprises a kettle type casing, a casing side vapor phase outlet, a casing side liquid phase inlet and a casing side liquid phase outlet, wherein the casing side vapor phase outlet is formed in the upper end of the kettle type casing; the casing side liquid phase inlet and the casing side liquid phase outlet are formed in the lower part of the kettle type casing; the kettle type casing is transversely divided into a front evaporation area and a rear evaporation area which are mutually connected in series through an overflow plate arranged in the middle of the kettle type casing; a front-end heat exchange pipe bundle and a rear-end heat exchange pipe bundle are respectively mounted in the front evaporation area and the rear evaporation area, and are respectively and hermetically connected through a front-end pipe plate, a rear-end pipe plate, a front-end pipe box and a rear-end pipe box; and different thermal fluid inlets are respectively formed in the front-end pipe box and the rear-end pipe box. The multi-fluid re-boiler provided by the invention has the benefits that the gasification rate of liquid at the tower bottom is easy to control, the piping is simple, the structure is compact, the casing utilization rate is high, steel products are saved, and the investment of re-boiling equipment at the tower bottom is reduced.