The invention discloses a camellia oleifera cake meal adhesive as well as a preparation method and an application thereof. Preparation raw materials of the camellia oleifera cake meal adhesive comprise components in parts by weight as follows: 100 parts of a viscosity regulator, 30-60 parts of camellia oleifera cake meal, 0.5-2 parts of a modifier, 8-30 parts of a crosslinking agent, 1-8 parts ofa curing agent, 5-15 parts of a diluent and 0.5-8 parts of filler, wherein the modifier comprises at least one of an anionic surfactant, a protein denaturant or alkali. The adhesive in the scheme hasgood application in manufacture of an artificial board. Compared with the prior art, the adhesive has the advantages that the preparation process is simple, safe, environmentally friendly and the like.