The invention discloses a quantum key and classic key integrated fusion encryption device and method. The device comprises a classic secret key request receiving module, a classic secret key generation module, a secret key encryption module, a quantum secret key random number generator, a classic secret key management module, a quantum secret key management module, a quantum secret key generationmodule, a quantum secret key negotiation module and a secret key sending module. According to the invention, the classic key generation module generates a classic asymmetric key; the quantum key random number generator, the quantum key generation module and the quantum key negotiation module generate a quantum key, and the key encryption module carries out encryption processing on an asymmetric key by adopting the quantum key for one time and then sends the asymmetric key to a request user or a service system through the key sending module. According to the invention, the secure transmission mode of the asymmetric secret key is expanded through a one-time one-secret absolute secure encryption mode, and the transmission efficiency and security of the asymmetric secret key are improved.