The invention discloses a composition for dispelling alcohol effects and protecting the liver. The composition is prepared from 15-70 parts of corn oligopeptide, 0.1-1 part of radix curcumae longae, 1-5 parts of rhizoma polygonati, 0.5-4 parts of grapefruit powder, 5-15 parts of kudzuvine root powder, 15-30 parts of hovenia dulcis thumb, 2-8 parts of a yeast extract, 0.5-2 parts of acerola cherrypowder, 0.2-2 parts of dried orange peel, 0.5-3 parts of radix liquiritiae, 0.3-2 parts of jujubes and 0.1-0.5 part of L-arabinose; the composition is prepared through technologies such as drying, mixing and tabletting. The composition has good effects of dispelling the alcohol effects and protecting the liver, especially, the medicine compatibility effect of the composition can significantly promote the effects of the corn oligopeptide on dispelling the alcohol effects and protecting the liver, the bitter taste of the oligopeptide product is reduced, and the adverse influence of the bitter taste on product application is avoided. Combination and compatibility are reasonable, the concentration of ethyl alcohol in blood can be significantly reduced, the liver function is enhanced, and the composition can quickly dispel the alcohol effects and prevent liver injuries.