The invention discloses a method, device and equipment for evaluating event HRA of a master control indoor system of a nuclear power plant, and a medium. The method comprises the steps of recognizinga cut set sequence causing a human error event; determining a personnel behavior unit in the cut set sequence; collecting personnel operation information corresponding to the personnel behavior unit;recording operation behavior information related to the human error event in the personnel operation information according to the time sequence to obtain corresponding operation error behavior relatedinformation; analyzing the control behavior of the operator by using the control error behavior related information to obtain a first behavior forming factor related to the event occurrence scene anda second behavior forming factor related to personnel cognition; and performing HRA evaluation on the system event in the master control room of the nuclear power plant by using the first behavior forming factor and the second behavior forming factor to obtain a corresponding HRA analysis result for representing the operation state of the nuclear power plant. According to the invention, more objective and accurate HRA evaluation of the nuclear power plant master control indoor system event can be realized.