The invention provides a whole vehicle logistics scheduling method and device, a computer readable medium and a logistics system. The method comprises the following steps: A, preprocessing original data to obtain effective and available order data and plate trailer data; B, generating a whole vehicle logistics scheduling scheme based on a Monte Carlo algorithm according to the order data and the plate trailer data; C, judging whether the generated logistics scheduling scheme of the whole vehicle is reasonable or not by utilizing constraint conditions, and if the generated logistics schedulingscheme of the whole vehicle is reasonable, reserving the logistics scheduling scheme of the whole vehicle; D, repeating the steps B-C, generating a next whole vehicle logistics scheduling scheme, comparing the next whole vehicle logistics scheduling scheme with the previous reserved whole vehicle logistics scheduling scheme, and reserving an optimal solution; E, circularly executing step D n-1 times, taking the reserved optimal solution as the final logistics scheduling scheme of the whole vehicle.