The embodiment of the invention discloses an image mapping method and device. The method comprises the steps of obtaining a two-dimensional image of a mold body and a three-dimensional model of the mold body in advance, according to the coordinates of the feature points on the mold body in the two-dimensional image and the coordinates in the three-dimensional model, constructing a coordinate mapping relation, wherein the coordinate mapping relation is a mapping relation between a coordinate system of the two-dimensional image and a coordinate system of the three-dimensional model; acquiring aguide wire puncture path planned based on a pre-established three-dimensional blood vessel model of a target object, wherein the guide wire puncture path is a puncture path from a puncture point of the target object to a lesion; and according to the mapping relationship, mapping the guide wire puncture path to a real-time acquired two-dimensional image of the target object blood vessel so as to guide a user to carry out real-time guide wire puncture. The purpose of guiding a user to carry out real-time guide wire puncture is achieved, and the problem that the guide wire penetrates through a blood vessel to bring life danger to a patient is solved to a certain degree.