The invention discloses an osteogenic polyether-ether-ketone craniomandibular internal fixation plate and a preparation method thereof. The preparation method comprises the following steps of: preparing a polyether-ether-ketone craniomandibular internal fixation plate; performing sandblasting on the surface of the polyether-ether-ketone craniomandibular internal fixation plate; performing ultrasonic cleaning on the fixation plate after sandblasting treatment; immersing the material in a simulated liquid for mineralization to obtain the osteogenic polyether-ether-ketone craniomandibular internal fixation plate. The fixation plate is subjected to the surface sandblasting treatment and the surface mineralization modification, and the surface roughness of the internal fixation plate after thesurface treatment is increased, a surface area is increased, and then the biomineralization is carried out to enhance the adhesion and biological activity of the coating.