The invention discloses a rock burst coal seam drilling-cutting-pressing-extraction-injection multi-disaster cooperative preventing method. Multiple coal seam drilled holes are constructed in a coal roadway in sequence; after the seam drilling construction reaches to a designed position, multiple hydraulic guide grooves are constructed by using high-pressure water jet in the drilling withdrawal process; then, the coal seam drilled holes are sealed, and are filled with high-pressure water for oriented hydraulic fracturing; after hydraulic fracturing, an extracting system is introduced for gas extraction according to a conventional method; when the coal seam drilled holes are from a working face for recovery by a certain distance, an extracting pipeline is canceled, and a coal seam water injecting pipe is introduced for water injection in coal seams; and coal mine fireproof stopping agents with a certain concentration are fed in the injected water. The method overcomes the time and spacerepeatability and the construction department difference in traditional rock burst coal seam multi-disaster preventing measures, and realizes cooperative integrated prevention of rock burst, gas, coal dust and coal seam spontaneous combustion of rock burst coal seams.