The invention relates to the technical field of hot-press forming machines, in particular to a hot-press forming machine with automatically replaceable molds. The hot-press forming machine comprises amachine body, two air cylinders are symmetrically arranged at the lower ends of hydraulic cylinders, shells are connected to the air cylinders, two clamping hands are symmetrically arranged on the inner wall of each through groove through one rotating shaft, threaded blocks are arranged on the side walls of screw rods, connecting rods are connected with the outer walls of the threaded blocks in asleeving mode, and the other ends of the connecting rods are connected with slide blocks. According to the machine, the clamping hands can be controlled to clamp the molds through the screw rods, thethreaded blocks and the slide blocks, motors are used to drive the clamping hands, so that the stability is high, the clamping force is large, and the molds do not fall off; the hydraulic cylinders and the air cylinders are arranged to move the molds, so that the moving speed is high, and the stability is high; and moreover, through the two clamping hands arranged on the two sides of the machinebody, the molds can be fed and taken away at the same time, so that the time is saved, the working efficiency is greatly improved, and the practicability is high.