The invention relates to a process preparation method of a super-lubricious antibacterial central venous catheter coating. According to the method, an ultrasonic spraying process is adopted to coat the coating onto the surface of a central venous catheter, so that the production of super-lubricious antibacterial single-cavity and multi-cavity central venous catheters can be realized; in addition,by ultrasonic spraying, a solution can be flushed to the surface of the central venous catheter to improve the firmness of the coating. The preparation method involved in the invention can improve theuniformity of the surface of the coating, is easy for industrial production, can reduce waste and air pollution, and saves cost.