The invention discloses a special compound fertilizer for tobacco and a preparation method and an application method of the compound fertilizer. The special compound fertilizer for tobacco comprises aspecial base fertilizer for tobacco and a special top-dress fertilizer for tobacco, wherein the weight ratio of N to P2O5 to K2O in the special base fertilizer for tobacco is (8-12):(11-16):(18-20),and the weight ratio of N to P2O5 to K2O in the special top-dress fertilizer for tobacco is (8-9):(0-4):(33-36). According to the invention, the maximum leaf area of Yunnan tobacco varieties and the maximum leaf area of Hongda tobacco varieties can be improved, and can be improved by 45-195 cm<2>.