The invention discloses a unit load collaborative standby optimization configuration method and system, equipment and a storage medium. The method comprises the following steps: establishing a unit load standby collaborative optimization correction model; establishing a demand response total amount constraint according to the success probability of the network attack and the load control mode of the power information physical fusion system demand response participating in the frequency modulation service; establishing upper and lower limit constraints of unit output adjustment and frequency constraints of a power system; solving a unit load standby collaborative optimization correction model under the total demand response constraint, the unit output adjustment upper and lower limit constraint and the power system frequency constraint; correcting the unit load standby configuration strategy according to the solution of the unit load standby collaborative optimization correction model;wherein the unit load standby collaborative optimization correction model is minCrsv = Cgen + Cdr, Cgen represents the standby cost of the generator, and Cdr represents the calling cost of the demandresponse resources. The method can maintain safe and stable operation of the power grid and is low in cost.