The invention provides a manufacturing method of a titanium steel composite plate. The manufacturing method comprises the steps that (1) surface cleaning and rust removal are carried out on a titaniumplate and a carbon steel plate; (2) the carbon steel plate is used as a base layer, and the titanium plate is used as a composite layer to be assembled into a basic composite layer; (3) ammonium nitrate explosives are used in a vacuum environment to conduct explosive cladding on the basic composite layer; and (4) stress relief heat treatment is carried out, and then cooling is carried out. The invention also provides the titanium steel composite plate manufactured by adopting the method. The manufacturing method can be used for producing the over-length and extra-large area titanium steel composite plate, and the manufacturing cost of the equipment can be saved; and the composite plate has excellent mechanical property and the corrosion resistance, and has broad application prospects.