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发明公开
CN110256462A 对氟苯基取代含色酮结构的螺[吲唑-异噁唑]衍生物及制备方法与应用 有权 转让

对氟苯基取代含色酮结构的螺[吲唑-异噁唑]衍生物及制备方法与应用
摘要：
本发明属于医药技术领域，尤其涉及对氟苯基取代含色酮结构的螺[吲唑-异噁唑]衍生物及制备方法与应用。本发明对氟苯基取代含色酮结构的螺[吲唑-异噁唑]衍生物的制备方法，包括如下步骤：（1）6-溴-4-氧-4H-苯并吡喃-3-甲醛肟的合成；（2）5-(4-氟亚苄基)-1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮的合成；（3）5-(4-氟亚苄基)-1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮和化合物6-溴-4-氧-4H-苯并吡喃-3-甲醛肟在氯胺T作用下发生1,3-偶极环加成反应得到对氟苯基取代含色酮结构的螺[吲唑-异噁唑]衍生物。
摘要（英）：

The invention belongs to the technical field of medicines and in particular relates to a p-fluorophenyl substituted spiro[indazole-isoxazole] derivative with a chromone structure and a preparation method and application. The preparation method of the p-fluorophenyl substituted spiro[indazole-isoxazole] derivative with the chromone structure comprises the following steps: (1) synthesizing 6-bromo-4-oxo-4H-benzopyran-3-formaldoxime; (2) synthesizing 5-(4-fluorobenzal)-1-phenyl-6,7-dihydro-1H-indazol-4(5H)-one; and (3) carrying out a 1,3-dipolar-cycloaddition reaction on the 5-(4-fluorobenzal)-1-phenyl-6,7-dihydro-1H-indazol-4(5H)-one and the compound 6-bromo-4-oxo-4H-benzopyran-3-formaldoxime under the action of chloramine T, so as to obtain the p-fluorophenyl substituted spiro[indazole-isoxazole] derivative with the chromone structure.

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