The invention discloses a safety prevention and control method for a fracture of a shaft wall of a deep vertical shaft. The method comprises the specific steps that firstly, one safety comprehensive prevention and control evaluation is carried out on the shaft once a month, a position head where the shaft wall falls off is found in time, and the possible water outlet condition of the shaft is evaluated; secondly, three reinforcing means of shaft wall reinforcement, inter-wall grouting filling and surrounding aquifer grouting reinforcement are adopted, the hidden danger of water outlet is overcome, and the falling part of the shaft is reinforced; thirdly, a resistance type and fiber grating type well wall strain and temperature monitoring system is installed in the shaft in advance; fourthly, emergency facilities are set in advance; and fifthly, some measures are adopted when an emergency condition occurs. The prevention and control system provides a safe and reliable working environment for most kilometer vertical shafts with huge thick surface soil layers, improves the life safety of workers, and provides a good foundation for future shaft safety prevention and control systems.