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发明公开
CN110305004A 放射性碘标记15-（4-碘苯基）-3（R,S）-甲基十五烷酸的制造方法 有权

放射性碘标记15-（4-碘苯基）-3（R,S）-甲基十五烷酸的制造方法
摘要：
本发明的课题在于提供在商业生产规模的大量合成中制造步骤的处理简便、并且不需要大量的有机溶剂的放射性碘标记15-(4-碘苯基)-3(R,S)-甲基十五烷酸的制造方法。本发明的解决方案为提供放射性碘标记BMIPP的制造方法，所述制造方法包括下述工序：标记工序，由15-(4-碘苯基)-3(R,S)-甲基十五烷酸(BMIPP)和放射性碘，通过碘交换反应得到放射性碘标记BMIPP；和纯化工序，通过液液萃取法对放射性碘标记BMIPP进行纯化。
摘要（英）：

The object of the present invention is to provide a radioactive iodine-labeled 15-(4-iodophenyl)-3(R,S)-methylpentadecanoic acid which is simple to process in a large-scale synthesis on a commercial production scale and does not require a large amount of organic solvent. Method for producing pentadecanoic acid. The solution of the present invention is to provide a manufacturing method of radioactive iodine-labeled BMPIP. The manufacturing method includes the following steps: a labeling step consisting of 15-(4-Iodophenyl)- 3 (R, S)-Methylpentadecane Acid (BMPIP) and radioactive iodine, radioactive iodine-labeled BMPIP is obtained through an iodine exchange reaction; and a purification process, the radioactive iodine-labeled BMPIP is purified by a liquid-liquid extraction method.

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