The application discloses a pressure sensor array applied in a pulse diagnosis device. The pressure sensor array comprises N rows of pressure sensor sets, each row of the pressure sensor sets comprises a plurality of pressure sensors in a preset spaced arrangement, each pressure sensor in an i-th row is longitudinally staggered with each pressure sensor in an (i plus 1)-th row, each pressure sensor in the first row is aligned with each pressure sensor in the n-th row, and i is 1, 2, ..., N-1; and each pressure sensor is used for acquiring pressure value of target pulses. In a practical application, by adopting the scheme of the application and conducting staggered arrangement of each pressure sensor, the pressure sensor array is improved in spatial resolution and improves an accuracy rateof pulse detection by the pulse diagnosis device. The application also discloses the pulse diagnosis device and has above-mentioned beneficial effects.