A profile clamping control method comprises the following steps that profile contour data information is read; contour data information is analyzed, a maximum circumscribed quadrangle of profile is constructed, and the profile is accommodated in the maximum circumscribed quadrangle; a bottom edge is selected, a maximum side length of the maximum circumscribed quadrangle is calculated, the maximumside length is used as the bottom edge, and a vertical line is drawn in the bottom edge range; whether the leftmost point and the rightmost point of the bottom edge are points on the outermost sides of the profile and vertically intersect with the vertical line as a straight line or not is checked, if not, the current profile cannot be clamped, the profile is replaced, and cutting machining is stopped; if yes, the process goes to the next step; whether the area of contact points of all the edges of the maximum circumscribed quadrangle and the profile contour meets the set size requirement or not is further judged, and if yes, the current profile can be clamped; and if not, the current profile cannot be clamped, the profile is replaced, and cutting machining is stopped. Through the method,various profiled bars can be clamped conveniently, and the machining applicability is ensured.