The invention relates to the technical field of power grid dispatching, in particular to a method for predicting short-term load curve of a 110kV main transformer of a power grid. The method comprisesthe following steps of: obtaining predicted current curves of all 10kV feeder lines of a power grid in the future 48 hours; traversing each 110kV main transformer of the power grid; acquiring equipment information, establishing a constraint condition according to a tide direction and a voltage level, and topologically obtaining all 10kV feeder lines mounted under a 110kV main transformer; superposing the prediction current curves of all 10kV feeders mounted under the 110kV main transformer to obtain prediction curve data of the 110kV main transformer; obtaining a predicted load curve of all 110kV main transformers of the power grid in the future 48 hours; and correcting the predicted load curves of all 110kV main transformers in the future 48 hours to form a final 48-hour predicted load curve. Real-time topology analysis can be carried out, the main transformer load composition is rapidly and automatically analyzed through a power failure maintenance single correction mechanism, thenhistorical data of each load composition element is fitted, a main transformer short-term load curve is generated, the timeliness is high, and the accuracy is high.