The invention provides a manufacturing method of a combined radiation guide plate. The manufacturing method includes the steps of generating a virtual guide plate model according to a virtual oral cavity model of the oral cavity of a patient; adjusting and fixing the position of the virtual guide plate model; processing the virtual guide plate model to obtain a virtual radiation guide plate base model; generating a virtual denture dentition model according to denture data; adjusting and fixing the position of the virtual denture dentition model; processing the virtual denture dentition model to get a to-be-printed virtual denture dentition model; obtaining a denture dentition and a radiation guide plate base. The manufacturing method has the advantages that the combined radiation guide plate which is composed of the radiation guide plate base and the denture dentition is provided, the patient can take CT by wearing the radiation guide plate base so as to determine the implant positionof a denture, then the denture dentition is inserted in the radiation guide plate base to take CT alone, the pre-examination of the patient with residual teeth in the oral cavity for denture preparation is greatly facilitated, and the precision of denture preparation is effectively improved.