The invention discloses an anti-slip ceramic tile with the asphalt fine sand imitation surface and a manufacturing method of the anti-slip ceramic tile. The manufacturing method includes the steps: A,an asphalt fine sand original surface is premade and subjected to 3d scanning, and asphalt fine sand texture patterns and asphalt fine sand bump texture patterns are obtained; B, a blank is subjectedto pressing forming, placed in a roller kiln to be dried, and engraved according to the asphalt fine sand bump texture patterns, and a ceramic tile green body is obtained; C, base overglaze is applied to the ceramic tile green body, and a base overglaze layer is obtained; D, according to the asphalt fine sand texture patterns, ink is applied to the base overglaze layer through an inkjet printingtechnology, and a pattern correction layer is obtained; E, transparent protection glaze is applied to the pattern correction layer, and a transparent protection glaze layer is obtained; and F, a material is put into the kiln to be subjected to firing forming, and the anti-slip ceramic tile with the asphalt fine sand imitation surface is obtained. The anti-slip ceramic tile with the asphalt fine sand imitation surface has the asphalt fine sand texture patterns and the asphalt fine sand bump texture, and achieves the bump effect of asphalt fine sand and the texture effect of the asphalt fine sand.