The invention relates to a histone acetyltransferase (HAT) inhibitor, provides a compound represented by a general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotopically-labeled compound (including deuterium-substitution) thereof, a preparation method thereof, a pharmaceutical composition containing the compound, and a use in treatment of various HAT related diseases or disorders thereof.