The invention relates to the technical field of in-situ leaching exploitation and provides a method for arranging high-altitude thick weathering crust leaching type rare earth ore in-situ leaching liquid injection wells. The method for arranging the high-altitude thick weathering crust leaching type rare earth ore in-situ leaching liquid injection wells comprises the following steps that firstly,grids are arranged on the surface of the ore body, and grid point liquid injection wells are arranged in grid points of the grids; secondly, after the grid point liquid injection wells are arranged, grid central liquid injection wells are arranged in centers of the multiple grid point liquid injection wells gathered together; thirdly, after each grid point liquid injection well and each grid central liquid injection well are arranged, a leaching liquid is injected into each grid point liquid injection well and each grid central liquid injection well; and fourthly, flow guide holes are preparedin the ore body in an outward-extending manner, and a rare earth leached liquid treated by the leaching agent is guided to flow out through the flow guide holes. According to the method for arrangingthe high-altitude thick weathering crust leaching type rare earth ore in-situ leaching liquid injection wells, plum blossom-shaped liquid injection wells and a cyclic liquid injection method are adopted; a joint surface is effectively penetrated through; channeling is avoided or reduced so that more leaching liquid can be in sufficient contact with the ore body; the leaching blind zone is reducedgreatly; the rare earth recycling rate is improved; and the recycling cycle of rare earth ore is shortened.