The invention discloses an anti-leakage sealing method of a double-stage material push centrifugal machine. The anti-leakage sealing method is characterized in that negative pressure is generated in aliquid cavity between a housing and an outer rotary drum so that in the process that an inner rotary drum does an axial reciprocating action during work of the centrifugal machine, the pressure of asolid cavity is larger than or equal to the pressure of the liquid cavity all the time; and the part, where the negative pressure is generated, of the liquid cavity is located in a drying area corresponding to an outer rotary drum filter cake concentrating part. In the working process of the centrifugal machine, the phenomenon that liquid in the liquid cavity back flows to a solid collecting cavity through a baffle, and the solid moisture percentage is increased is avoided or reduced, and therefore the solid-liquid separation effect is improved; and when the centrifugal machine stops working,an external negative-pressure pump system does not affect work such as demounting of a centrifugal machine body at all, a dynamic sealing device also retracts to reset under the effect of an elastic part, a certain distance is maintained between the dynamic sealing device and the housing, and demounting of the housing is not affected as well.