The invention discloses a self-propelled combine-harvester. The self-propelled combine-harvester comprises a main body frame and an armrest, a power box and a harvesting mechanism which are arranged on the main body frame, wherein the front and rear sides of the main body frame are provided with walking wheels, the walking wheels are rotationally connected to the main body frame through rotating shafts, and the power box is in transmission connection to the rotating shaft at one side through a chain wheel set; each walking wheel comprises a main wheel body, wherein each main wheel body is provided with at least three sliding grooves, antiskid ribs are slidably clamped in the sliding grooves, and the antiskid ribs are driven by a driving assembly to move back and forth in the radial directions of the main wheel bodies. The self-propelled combine-harvester has the advantages that the multiple antiskid ribs stretching and retracting in the radial directions are arranged in the main wheelbodies so that the whole device not only can move smoothly on the flat road surface, but also can avoid slipping in a farmland, and has higher practicability.