The invention discloses a skin chip for gas-liquid phase culture. The skin chip comprises an upper plate, a middle plate, a porous membrane and a bottom plate, which are successively arranged up and down. The bottom surface of the upper plate is provided with a gas channel which is concave upward. The skin chip also comprises a gas inlet and a gas outlet which are arranged on the skin chip. The gas inlet and the gas outlet are respectively led to two ends of the gas channel. A through groove penetrates through the middle plate. The through groove is located below the gas channel. The porous membrane is located below the through groove and covers the bottom of the through groove. The upper surface of the bottom plate is provided with a culture medium channel which is concave downward. The culture medium channel is located below the through groove and is communicated with the through groove through the porous membrane. The skin chip also comprises a culture medium inlet and a culture medium outlet which are arranged on the skin chip. The culture medium inlet and the culture medium outlet are respectively led to two ends of the culture medium channel. The invention has the following advantages: nutrients can be provided in time and metabolic waste can be removed timely; there is no need to replace fresh culture mediums frequently; and manpower and material resources are saved in the culture process.