The invention discloses a water shut-off and profile control method aiming at an extra-high-water-cut-period oil deposit. The method comprises the steps of (1) according to a remaining oil distribution characteristic, determining a water drive zone type of a target oil deposit reservoir, wherein the water drive zone type comprises three levels: an extreme water washing zone, a high water-flooded zone and a weak water drive zone, and the water flooding degrees of the extreme water washing zone, the high water-flooded zone and the weak water drive zone are sequentially decreased progressively; (2) when the target oil deposit reservoir comprises the extreme water washing zone, determining a corresponding water shut-off and profile control system and the system dosage according to reservoir characteristic parameters of the type of water washing zone; and (3) and carrying out water shut-off and profile control on a well section and the depth of the extreme water washing zone based on the water shut-off and profile control system and the system dosage. The method builds a scientific reservoir water drive level classification standard based on water shut-off and profile control aiming atextra-high-water-cut-period reservoir development characteristics and remaining oil distribution, and builds a new extra-high-water-cut oil field depth water shut-off and profile control method aimingat the extreme water washing zone in the classification standard at the same time, so that a water shut-off and profile control effect of the extra-high-water-cut oil deposit is favorably improved.