The invention discloses an anti-tumor combination drug and application thereof. The combination drug is prepared from sorafenib and sodium nitroprusside, the drug concentration ratio of sorafenib to sodium nitroprusside is 1 to (2 to 64), preferably, the concentration of sorafenib is 2.5 [mu]M, and the concentration of sodium nitroprusside is 160 [mu]M. The anti-tumor combination drug significantly improves the inhibitory effect of sorafenib on hepatocellularcarcinoma cells, and has a synergistic effect; under the premise of ensuring the same therapeutic effect, sodium nitroprusside and sorafenib are combined to use to reduce the dosage of sorafenib, so that toxic and side effects are reduced; and as a widely used clinical drug, sodium nitroprusside is low in cost and can reduce the cost of treatment and reduce the economic burden of patients by being combined with sorafenib.