The invention relates to a manufactured sand production process, in particular to a high-quality manufactured sand production process with a sand grinder and dry-method centrifugal powder removal andclassification. The high-quality manufactured sand production process with the sand grinder and dry-method centrifugal powder removal and classification comprises 19 working procedures such as mining,manufacturing sand, shaping, removing powder, classifying, modulating and grading. The process can be used for manufacturing manufactured sand for concrete in C50 and above. A Germany produced RPM sand manufacturing machine is adopted, and a horseshoe gap is adjusted appropriately, so that elongated and flaky manufactured sand is reduced; by adopting an assembly line work sand grinder, edges andcorners of the manufactured sand can be eliminated, the concrete flowability is improved, and the strength is stable; and by adopting a dry-method centrifugal constant linear velocity rotary table, powder is removed and is classified in to six grades according to the standard, and modulation and reasonable grading are carried out, so that the defects of high mud powder content and incomplete grading of wet-method washed-out sand are overcome. The production process is scientific, reasonable, economical and applicable, solves the technical problem that high-quality manufactured sand is in severe shortage in the market since natural sand is restricted due to environment protection in the process of using the manufactured sand for producing the concrete in C50 and above, and fills a technicalgap in the domestic building industry.