The invention discloses an automatic lock-up control device for theft prevention of an automobile. The device comprises an automobile door body, an operating table and a lock case. An outer handle andan inner handle are separately arranged on the outer side face and the inner side face of the automobile door body, a lock groove is formed in one side of a center line position of the inner side face of the automobile door body, the operating table is arranged on the outer surface of the lower end position of the inner side face of the automobile door body, a lock-up switch and a lock-rising switch are parallelly arranged on the top of the operating table, the lock case is arranged in the automobile door body in the lock groove position, an electric telescopic rod is arranged above the lockgroove in the lock case, a lock plate is arranged in the lower end position in the lock case, the lock plate is slidably sleeved on a first fixed column, a first reset spring is slidably sleeved on the outer surface of the first fixed column, an operating plate is arranged in the upper end position in the lock case, the operating plate is slidably sleeved on a second fixed column, and a second reset spring is slidably sleeved on the outer surface of the second fixed column on the outer side of the operating plate. The lock-up device is good in theft-preventing effect and high in safety.