The invention provides a navigation route generation method and device for automatic drive, and an automatic driving system, and belongs to the field of the automatic drive. The generation method comprises the following steps: acquiring related information of a planning path on a navigation map; mapping the related information of the planning path to a previously acquired high-precision map, and acquiring high-precision path information corresponding to the related information of the planning path on the high-precision map; screening out key location points at least including the intersectionlocation from the high-precision path information; inserting the preset amount of supplementary location points between the key location points, wherein the supplementary location point is extracted from the high-precision path information; computing according to the information of the key location point and the supplementary location point and generating a global navigation path for the automaticdrive. The navigation route generation method and system and the automatic driving system provided by the invention can improve the efficiency of generating a follow-up path for automatic driving, the flexibility and the instantaneity.