The invention discloses a micro-vortex mixing reaction device. The micro-vortex mixing reaction device comprises a tube cylinder and a turbulent flow assembly which is disposed in the tube cylinder, wherein the turbulent flow assembly includes an orifice plate and a vortex generating nozzle which is formed in the orifice plate. Compared with the prior art, the micro-vortex mixing reaction device has the advantages that the mixing reaction device has no easy clogging and convenient use, eddy current can be generated effectively, the volume of vortexes in a pipeline is reduced, and the number ofthe vortexes can be increased greatly; meanwhile, the strength and rigidity of the device can be increased greatly, the service life of the device can be prolonged, the cross section of water is changed, and the flow state of water flow can be changed sharply, so that a high-density high-ratio micro-vortex is formed; and turbulent flow is reinforced, the number of the micro-vortex is increased greatly, and the flow field of the micro-vortex can be distributed uniformly.