The invention provides a personalized total temporal-mandibular joint osteotomy replacement locating guide plate. The personalized total temporal-mandibular joint osteotomy replacement locating guideplate includes a zygomatic arch osteotomy guide plate and a condylar process guide plate. The zygomatic arch osteotomy guide plate is attached to the outer side surface of zygomatic arch. A retentionhole matched with a total temporal-mandibular joint prosthesis zygomatic arch retention part is arranged on the surface of the zygomatic arch osteotomy guide plate. A guide platform is arranged on theedge of the lower part of the zygomatic arch osteotomy guide plate. The condylar process guide plate includes a condylar process head end, a guide groove, a guide platform and an underjaw ascending limb end. The condylar process head end is attached to a diseased condylar head. A retention hole is formed in the surface of the condylar process head end. The underjaw ascending limb end is attachedto the upper half part of an underjaw ascending limb. A retention hole matched with the upper half part of a total temporal-mandibular joint prosthesis ascending limb retention part, the guide grooveis formed in the lower end of the condylar process head end, and the guide platform is arranged on the edge of the guide groove. The guide plate is good in stability, meanwhile, the guide plate retention holes correspond to the retention holes of the prosthesis, the osteotomy range is accurate, the accuracy of the prosthesis retention is ensued, the intermaxillary ligation before implantation is avoided, the operation time is shortened, and surgical trauma is reduced.