The invention discloses a tubing-casing annulus pressurizing setting tubing anchor, and relates to the technical field of oilfield downhole tools. The tubing-casing annulus pressurizing setting tubinganchor comprises an upper joint, a lower joint, a central pipe, and an anchoring mechanism, a spring claw is machined at the upper end of a slip sleeve, the spring claw is hooked to the lower end ofthe slip setting piston sleeve to connect the anchoring mechanism as a whole, the slip setting piston sleeve and the central pipe are connected through a positioning dowel to integrally connect the integrated anchoring mechanism to the central pipe, and the slip setting piston sleeve is provided with a liquid passing hole used for introducing pressure into a piston cavity. According to the tubing-casing annulus pressurizing setting tubing anchor, the structure of the anchoring mechanism is improved, after an oil pipe is heated and stretched, the positioning dowel is sheared by stress, and after being sheared, the anchoring mechanism as a whole can slide freely on the central pipe so as to adapt to thermal expansion and contraction; and in this telescopic mechanism, the central pipe is directly used as a telescopic slide pipe, and thus the adverse effect brought by reduction of the diameter of a pipe column is eliminated.