The invention discloses an air purification device for treating pollutants. The device comprises an outer shell and purification outlets distributed at the top of the outer shell, an installation bottom plate is horizontally arranged at the bottom end in the outer shell, an activation treatment box body is installed in the center of the installation bottom plate, an activation treatment mechanismis installed in the activation treatment box body, two adjusting and limiting mechanisms connected with the activation treatment box body are symmetrically distributed at the bottom end of the activation treatment mechanism, and an ultrasonic sprayer is installed under the activation treatment mechanism, and an air pumps and a water pump are mounted on the left side and the right side of the installation bottom plate correspondingly. The air purification device has the advantages of good disinfection and sterilization effect and good filtering effect, scientifically and effectively purifies air pollutants, ensures that the purified indoor ozone does not exceed the standard, is economical and practical, and has good practical and popularization values.